Topical refers to any medication, product, or treatment applied directly to a body surface, most commonly the skin, to produce its effects right where it’s placed. A topical medication is a medication that is applied to a particular place on or in the body. Most often, topical medications are applied to the skin or mucous membranes, via creams, foams, gels, lotions, or ointments. [1] Define topical. topical synonyms, topical pronunciation, topical translation, English dictionary definition of topical. adj. 1. Being of current interest or relevance: topical issues. TOPICAL definition: 1. of interest at the present time; relating to things that are happening at present: 2. A topical…. Learn more. When some information or news is current and of immediate interest, we say it is topical. This might be a news story or a bit of gossip, or just a subject that is of current importance. When some information or news is current and of immediate interest, we say it is topical. This might be a news story or a bit of gossip, or just a subject that is of current importance. If it's now, it's topical. Noun topical (plural topicals) A substance, especially a medication, applied externally (to the surface of the skin or eye). Discover Topicals now at Sephora! Shop now, and pay in 4 interest-free payments later with Klarna! Like a topical medicine, a topical reference or story applies to something specific, focusing on a topic that's currently in the news. TV comedians often use topical humor, making jokes about a currently popular movie or the latest political scandal—if possible, one that just broke that same day. Topicals is transforming the way you feel about skin through effective science backed products for chronic skin conditions and mental health advocacy.